Variants
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rs1603275152

  • Uncertain significance

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Description

The p.S1129Y variant (also known as c.3386C>A), located in coding exon 19 of the BRIP1 gene, results from a C to A substitution at nucleotide position 3386. The serine at codon 1129 is replaced by tyrosine, an amino acid with dissimilar properties. This amino acid position is highly conserved in available vertebrate species. In addition, this alteration is predicted to be tolerated by in silico analysis. Since supporting evidence is limited at this time, the clinical significance of this alteration remains unclear.

Reference Allele

G


Alternative Allele

T

Chromosome

17


Location

61683660


Variant Type

SNP

Genes

ClinVar

Name

NM_032043.3(BRIP1):c.3386C>A (p.Ser1129Tyr)


Allele

T


Clinical Significance

Uncertain significance

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