CLCN2 Gene
chloride voltage-gated channel 2
ALIAS SYMBOLS
CLC2
EJM6
ClC-2
Your Results
Sign InDescription
The CLCN2 gene belongs to the CLC family of genes, which provide instructions for making chloride channels. These channels, which transport negatively charged chlorine atoms (chloride ions), play a key role in a cell's ability to generate and transmit electrical signals. Some chloride channels regulate the flow of chloride ions across cell membranes, while others transport chloride ions within cells.
The CLCN2 gene provides instructions for making a chloride channel called ClC-2. These channels are embedded within the outer membrane of most cells, and they transport chloride ions in and out of cells. The channel's function is thought to be particularly important in nerve cells (neurons) in the brain. The ClC-2 channel regulates the size (volume) of neurons by playing a role in the intake and release of water as well as maintaining a normal balance of ions in cells.
CHROMOSOME
3
LOCATION
q27.1
LOCUS TYPE
gene with protein product
VARIANTS
162
External Links
HGNC
Ensembl
NCBI
OMIM