OPA1 Gene
OPA1 mitochondrial dynamin like GTPase
ALIAS SYMBOLS
NTG
KIAA0567
FLJ12460
NPG
MGM1
Your Results
Sign InDescription
The OPA1 gene provides instructions for making a protein that is found in cells and tissues throughout the body. The OPA1 protein is active in the inner membrane of cell structures called mitochondria, which are the energy-producing centers in cells. Mitochondria are dynamic structures that change shape through processes called fission (splitting into smaller pieces) and fusion (combining pieces). Changes in shape are necessary for mitochondrial function and the production of new mitochondria. The OPA1 protein helps to regulate the shape of mitochondria by playing a key role in the fusion process.
The OPA1 protein is also involved in a process that takes place in mitochondria called oxidative phosphorylation, from which cells derive much of their energy. Additionally, the OPA1 protein plays a role in the maintenance of the DNA within mitochondria, called mitochondrial DNA (mtDNA), and in controlled cell death (apoptosis).
CHROMOSOME
3
LOCATION
q29
LOCUS TYPE
gene with protein product
VARIANTS
611
Phenotypes
External Links
HGNC
Ensembl
NCBI
OMIM