SLCO1B3 Gene
solute carrier organic anion transporter family member 1B3
ALIAS SYMBOLS
OATP8
OATP1B3
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Sign InDescription
The SLCO1B3 gene provides instructions for making a protein called organic anion transporting polypeptide 1B3, or OATP1B3. This protein is found in liver cells; it transports compounds from the blood into the liver so that they can be cleared from the body. For example, the OATP1B3 protein transports bilirubin, which is a yellowish substance that is produced when red blood cells are broken down. In the liver, bilirubin is dissolved in a digestive fluid called bile and then excreted from the body. The OATP1B3 protein also transports certain hormones, toxins, and drugs into the liver for removal from the body. Some of the drugs transported by the OATP1B3 protein include statins, which are used to treat high cholesterol; heart disease medications; certain antibiotics; and some drugs used for the treatment of cancer.
CHROMOSOME
12
LOCATION
p12.2
LOCUS TYPE
gene with protein product
VARIANTS
151
Phenotypes
External Links
HGNC
Ensembl
NCBI
OMIM