Variants
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Glaucoma 3, primary congenital, D

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Description

Primary congenital glaucoma (PCG) is characterized by elevated intraocular pressure (IOP), enlargement of the globe (buphthalmos), edema, and opacification of the cornea with rupture of Descemet's membrane (Haab’s striae), thinning of the anterior sclera and iris atrophy, anomalously deep anterior chamber, and structurally normal posterior segment except for progressive glaucomatous optic atrophy. Symptoms include photophobia, blepharospasm, and excessive tearing. Typically, the diagnosis is made in the first year of life. Depending on when treatment is instituted, visual acuity may be reduced and/or visual fields may be restricted. In untreated individuals, blindness invariably occurs.

GeneReviews

  • Mode of Inheritance

  • Autosomal recessive inheritance

VARIANTS

202

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Genes

External Links

  • OMIM

    613086

  • Orphanet
  • HPO
  • Medgen

    C2751316

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