Variants
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Parietal foramina 2

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Description

Enlarged parietal foramina are characteristic symmetric, paired radiolucencies of the parietal bones, located close to the intersection of the sagittal and lambdoid sutures, caused by deficient ossification around the parietal notch, which is normally obliterated by the fifth month of fetal development. Enlarged parietal foramina are usually asymptomatic. Meningeal, cortical, and vascular malformations of the posterior fossa occasionally accompany the bone defects and may predispose to epilepsy. In a minority of individuals, headaches, vomiting, or intense local pain are sometimes associated with the defects, especially on application of mild pressure to the unprotected cerebral cortex.

GeneReviews

  • Mode of Inheritance

  • Autosomal dominant inheritance

VARIANTS

161

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Genes

External Links

  • OMIM

    609597

  • Orphanet
  • HPO
  • Medgen

    C1865044

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